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长时间但有限的抗原呈现促进了"无助"记忆CD8+T细胞的可逆缺陷

Verena van der Heide1, Gabriel Laghlali2, Bennett Davenport3

  • 1Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.

Immunity
|June 26, 2025
PubMed
概括

即使没有CD4+ T细胞的帮助,CD8+ T细胞的记忆形成也可能因急性感染期间长时间暴露在抗原中而受到损害. 然而,这些记忆缺陷是暂时的,随着时间的推移,可以恢复完整的记忆潜力.

关键词:
CD4(+) T细胞有助于T细胞的产生.CD8(+) T细胞的记忆体李斯特里亚单细胞原生菌Listeria monocytogenes这是一种急性感染.流感A型病毒感染者.淋巴细胞冠状淋巴炎病毒.疫苗病毒病毒病毒病毒病毒."无助"的记忆是没有帮助的.

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