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Updated: Sep 18, 2025

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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开发基于BRET的化物生物传感器,用于高吞吐量选KCC2调节器

Charles S Lay1, Elvira Diamantopoulou1, Katharina L Dürr1

  • 1OMass Therapeutics, Building 4000, John Smith Dr, ARC, Oxford, OX4 2GX, UK.

SLAS discovery : advancing life sciences R & D
|June 26, 2025
PubMed
概括

研究人员开发了一种基于BRET的新型生物传感器Glorider,用于高通量化物离子传输调节器的选. 这种工具可以实时测量活细胞中药物效应的动力学测量,促进神经疾病的药物发现.

关键词:
生物传感器是一种生物传感器.化物 化物使用化物成像技术.药物发现研究.在KCC2中,KCC2是KCC2.雷特综合征是什么意思 雷特综合征查检查 查检查 查检查溶解物载体 溶解物载体

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
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