的多糖可通过调节肠道微生物群和代谢物来减轻动脉样硬化
Fanghong Zhu1, Tianlan Xi2, Qian Liu2
1Department of Traditional Chinese Medicine, The First Affiliated Hospital of the Air Force Medical University, China.
International journal of biological macromolecules
|June 26, 2025
概括
的多糖 (AP) 通过调节肠道细菌和代谢物来对抗动脉样硬化. AP治疗减少了大动脉病变和炎症,突出了它对心血管健康的潜力.
科学领域:
- 心血管研究研究心血管研究
- 微生物组科学 微生物组科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉样硬化是心血管疾病的主要原因,治疗选择有限.
- 来自阿斯巴拉古斯 (Asparagus cochinchinensis) 的粉多糖 (AP) 是一种潜在的治疗剂.
- AP在调节动脉样硬化肠道微生物群中的作用尚未被探索.
研究的目的:
- 在高脂肪饮食诱导的ApoE-/-小鼠模型中研究AP的抗动脉样硬化机制.
- 探索AP对肠道微生物群组成和代谢物概况的影响.
- 为了确定AP治疗效果的潜在生物标志物.
主要方法:
- 在使用高脂肪饮食 (HFD) 的ApoE-/-小鼠中诱导了动脉样硬化.
- 用AP治疗小鼠,并评估大动脉病变,血清脂质和炎症标志物.
- 用16S rRNA测序分析了肠道微生物组成.
- 进行了代谢分析,以确定关键代谢物.
主要成果:
- 在HFD养的小鼠中,AP治疗显著降低了大动脉病变和血清脂质水平.
- AP降低了主动脉中的促炎因素mRNA水平.
- AP调节了肠道微生物群,逆转了HFD诱导的Bacteroidetes和Firmicutes的变化,并增加了Actinobacteria.
- AP改变了便和血液中特定代谢物的水平,包括L-glutaminyl-L-tryptophan.
结论:
- 的多糖通过肠道微生物群-代谢物轴产生抗动脉样硬化作用.
- AP调节肠道微生物群的组成和关键代谢物水平,如L-glutaminyl-L-tryptophan.
- L-glutaminyl-L-tryptophan显示出作为一种新的生物标志物来监测AP在动脉样硬化中的治疗功效的潜力.
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