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通过EDC/NHS介导的化物对碳氧甲基基托桑进行修饰,以提高血液接触生物医学膜的性能
Zelin Liao1, Hui Yu2, Gaohong He3
1State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Ocean and Life Science, Panjin Campus, Dalian University of Technology, Panjin 124221, China; R&D Center of Membrane Science and Technology, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
International journal of biological macromolecules
|June 26, 2025
概括
聚硫 (PES) 膜的水友性修饰与碳氧甲基基托 (CMCS) 显著改善了血红相容性和抗菌性质. 经过修改的CMCS-PES膜显示蛋白质吸附和血液溶解减少,使其适用于与血液接触的应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 表面科学是一门学科.
背景情况:
- 接触血液的膜需要疏水性来防止泄漏,但往往表现出不良的血液相容性.
- 水友性修饰对于提高这种膜的生物相容性至关重要.
- 聚硫 (PES) 膜被广泛使用,但需要表面功能化以改善血液相互作用.
研究的目的:
- 开发一种水友性碳素甲基基托 (CMCS) 改性聚硫 (PES) 膜 (CMCS-PES).
- 为了评估修饰膜的血液相容性,抗菌活性,稳定性和气体透性.
- 建立一个有效的策略,以改善血液接触膜的血液相容性.
主要方法:
- 用CMCS通过热交联和化对PES膜的表面修改.
- 使用SEM,AFM,FTIR,XPS,BET和水接触角测量的表征.
- 系统评估血红相容性 (蛋白质吸附,血液溶解,凝固),抗菌活性,气体透和长期稳定性.
主要成果:
- 在CMCS-PES膜中,水接触角度显著降低 (30.9°,而 PES则为84.3°).
- 观察到明显改善的血液兼容性,包括减少蛋白质吸附 (BSA,BGG),降低血液溶解率 (0.3%与0.9%相比),延长激活的部分血栓形成时间,降低纤维素水平.
- 证明了对大肠杆菌 (28.9%的抑制) 和金黄色杆菌 (42.76%的抑制) 的良好的抗菌活性.
- 实现了具有竞争力的气体透性和优异的长期稳定性,防止血液泄漏和血小板粘附.
结论:
- 用CMCS对PES膜进行水友性修饰是一种有效的策略,可以提高血红相容性.
- 该CMCS-PES膜在减少血液物质相互作用和抑制细菌生长方面表现出卓越的性能.
- 这种修改后的膜具有先进的血液接触医疗器械的巨大潜力.
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