在大鱼 (Micropterus salmoides) 中对饮食碳水化合物利用的mTOR信号调节

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Meidong Lv¹, Kang Yang¹, Xuan Wang¹

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|June 26, 2025

概括

刺激大嘴的mTOR信号改善了生长和料利用. 这一途径增强葡萄糖代谢,降低血糖和增加胰岛素,为水产养殖料配方提供了一种策略.

科学领域:

水产养殖营养水产养殖营养
鱼类生理学鱼类生理学
分子信号通道的分子信号通道.

背景情况:

鱼表现出葡萄糖不耐受性,增加了因饮食中的碳水化合物而导致脂肪肝疾病的易感性.
在鱼类,特别是食肉动物中,调节葡萄糖代谢的确切机制尚不清楚.

研究的目的:

研究拉巴胺素 (mTOR) 信号通路的机械性标在大鱼 (Micropterus salmoides) 调节葡萄糖代谢中的作用.
评估mTOR刺激和抑制对这种水产养殖物种生长,料利用和代谢参数的影响.

主要方法:

一项为期8周的食试验,使用异和异脂饮食,并补充了白 (mTOR激活剂),拉巴 (mTOR抑制剂) 或对照剂.
分析生长性能,料利用率,血葡萄糖和胰岛素水平,肝糖解和TCA循环活性,ATP水平,AMPK酸化,SREBP1活性,肝脂和糖原含量.

主要成果:

mTOR刺激显著改善了生长性能和料利用率,而抑制则产生了不良影响.
mTOR刺激导致血葡萄糖降低和胰岛素水平增加.
通过mTOR刺激观察到增强的葡萄糖分解和TCA循环活性,肝脏ATP升高,抑制AMPK酸化,降低SREBP1活性,降低肝脏脂质,增加糖原含量.

结论:

mTOR信号激活促进大嘴鱼的食后葡萄糖利用.
针对mTOR信号提供了一个潜在的策略,以提高水产养殖料配方中的食碳水化合物耐受性.

关键词:

葡萄糖的新陈代谢.增长的增长增长的增长大嘴巴低音是什么意思脂质代谢脂质的代谢在mTOR信号通道上.

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