成本结果路径框架:将社会经济影响与不利结果路径整合起来,以支持决策者
Thibaut Coustillet1, Angela Bearth2, Xavier Coumoul1
1Université Paris Cité, HealthFex, INSERM, 45 rue des Saints-Pères, Paris 75006, France.
Toxicology
|June 26, 2025
概括
我们引入了成本结果路径 (COPs),将化学物质暴露与社会经济成本联系起来,扩大了不利结果路径 (AOP) 框架. 这种方法量化了环境诱导疾病的经济影响,以更好地管理风险.
科学领域:
- 环境毒理学环境毒理学
- 卫生经济学 卫生经济学
- 风险评估 风险评估
背景情况:
- 不良结果途径 (AOP) 框架是为化学风险评估而建立的,但缺乏社会经济影响分析.
- 环境引起的疾病产生了重要的社会经济成本,这与风险管理和优先考虑有关.
研究的目的:
- 通过将不利结果 (AO) 与成本结果 (CO) 联系起来,提出成本结果途径 (COP).
- 将化学物质暴露的社会经济成本纳入AOP框架.
- 开发一个新的框架来评估环境相关疾病的经济负担.
主要方法:
- 该研究提出了AOP框架的概念扩展.
- 设计了一个新的成本结果路径 (COP).
- 进行了一项以神经发育毒性为重点的in silico病例研究.
主要成果:
- 拟议的COP将不良结果"智商下降"与成本结果"社会经济负担增加"联系起来.
- 该框架量化了化学物质暴露的社会经济影响,例如儿童的智商下降.
- 该案例研究表明,将特定的准许使用权与更广泛的COs联系起来是可行的.
结论:
- 成本结果路径 (COPs) 提供了一种将社会经济影响纳入化学风险评估的方法.
- 这种框架可以通过强调环境暴露的经济后果来支持公共卫生政策制定.
- 会议会议的方法对各种具有重大社会经济负担的疾病有潜在的应用,包括癌症,肥胖和神经退行.
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