甲毒性:一个案例报告和现有文献的系统审查
Abigail Clark1, Jordan Hildenbrand1, Lauren Gensler1
1Department of Medicine, Emory University School of Medicine, Atlanta, GA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
概括
甲 (PDCB) 是一种有毒化学物质,存在于球和所除臭剂中. 摄入可引起严重的神经和身体症状,特别是在缺铁性贫血的年轻女性中,突出显示需要增加临床怀疑.
科学领域:
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
- 皮肤病学 皮肤病学
背景情况:
- 甲 (PDCB) 是家用产品中常见的化学物质,如球和所碗除臭剂.
- 摄入PDCB,无论是急性还是慢性,都可能导致影响多个器官系统的毒性,包括大脑,脏,肝脏和皮肤.
研究的目的:
- 调查临床表现和与PDCB毒性相关的风险因素.
- 系统地审查PDCB毒性的人类病例,以确定常见发现和有风险人群.
主要方法:
- 使用多个数据库 (PychINFO,CINAHL,Web of Science,OVID/Medline) 进行了系统的文献审查,以确定报告的人类PDCB毒性的病例.
- 一个案例报告介绍了一名32岁的女性,由于摄入PDCB而出现亚急性认知衰退和皮疹.
主要成果:
- PDCB毒性可以表现为显著的,尽管非特定的,神经精神病,皮肤和神经成像异常.
- 系统性审查确定了18个PDCB毒性的相关记录.
- 一个案例研究突出了一个患有周周结节性白细胞大脑病变和二次因长时间摄入所碗除臭剂而引起的阴性皮疹的患者.
结论:
- 临床医生应该怀疑有毒的摄入,特别是当脑病变的原因不清楚时,并收集详细的附带病史.
- 患有缺铁性贫血和有药物使用史的年轻女性可能面临PDCB毒性的风险增加.
- 帕拉迪二 (PDCB) 应被视为一种潜在的滥用物质.
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