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细胞因子交响曲:解读瘤微环境和口腔癌中的转移轴
Mukesh Kumar Manickasamy1, Ravichandran Vishwa1, Bandari BharathwajChetty1
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam 781039, India.
Cytokine & growth factor reviews
|June 26, 2025
概括
瘤微环境 (TME) 中的细胞因子通过促进侵袭和免疫抑制来驱动口腔癌转移. 准这些细胞因子为控制口腔癌进展提供了一个有希望的策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 口腔癌是一种致命的疾病,具有高转移潜力和有限的治疗成功.
- 瘤微环境 (TME) 在通过细胞相互作用和免疫调节来调节口腔癌转移方面至关重要.
- 细胞因子是TME中的关键分子媒介,影响炎症,免疫反应和转移过程.
研究的目的:
- 审查细胞因子在调节口腔癌转移的TME中的作用.
- 探索复杂的细胞因子网络及其对瘤进展和转移传播的影响.
- 讨论口腔癌治疗的新兴细胞因子向策略.
主要方法:
- 文献综述侧重于口腔癌TME中的细胞因子网络.
- 在转移中对前瘤和抗瘤细胞因子功能的分析.
- 检查细胞交叉 (免疫细胞,TAM,CAF) 和其在细胞因子介导转移中的作用.
主要成果:
- 亲瘤性细胞因子 (例如IL-6,IL-8,TGF-β) 促进表皮细胞-介质细胞过渡 (EMT),细胞外基质 (ECM) 重塑和免疫逃避.
- 抗瘤细胞因子 (例如,IFN-γ,IL-12) 在免疫抑制性TME中经常被下调,阻碍免疫激活.
- 瘤细胞,免疫细胞,TAM和CAF之间的细胞因子交叉扩大口腔癌转移.
结论:
- 了解TME中的细胞因子网络对于开发针对口腔癌转移的向疗法至关重要.
- 新兴的策略包括准IL-6/STAT3,IL-8和利用免疫检查点抑制剂来调节TME.
- 需要进一步的临床研究来验证在口腔癌中精准医学中基于细胞因子的干预措施.
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