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Updated: Sep 18, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Published on: June 8, 2022

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从Gq-bound PTH1R的冷-EM结构中了解G蛋白合偏好

Fumiya K Sano1, Kota Shimizume2, Kazuhiro Kobayashi3

  • 1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Nature chemical biology
|June 26, 2025
PubMed
概括

结构洞察力揭示了甲状腺激素类型1受体 (PTH1R) 如何通过Gq. 了解这些机制是开发新的骨质疏松症治疗方法的关键,通过选择性向Gs信号.

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