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Updated: Sep 18, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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对压力的 lysosomal 监测反应延长了健康spanpan

Terytty Yang Li1,2, Arwen W Gao3,4, Rendan Yang5

  • 1State Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Laboratory of Longevity and Metabolic Adaptations, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. teryttyliyang@fudan.edu.cn.

Nature cell biology
|June 26, 2025
PubMed
概括

沉默C. elegans中的真空H+-ATPase子单元可以提高 lysosomal 功能,将寿命延长60% 这种溶酶体监测反应 (LySR) 增强了蛋白质分解,并在神经退行性疾病模型中清除聚合物.

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