用乙醇辅溶剂提高硫沙拉在超临界二氧化碳中的溶解度:一项综合性研究
Hadil Faris Alotaibi1, Suleiman Ibrahim Mohammad2,3, Asokan Vasudevan4
1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint AbdulRahman University, 11671, Riyadh, Saudi Arabia. hfalotaibi@pnu.edu.sa.
Scientific reports
|June 26, 2025
概括
作为辅溶剂添加乙醇显著提高了硫沙拉在超临界二氧化碳 (CO2) 中的溶解度. 在特定的温度和压力下观察到的这种增强的溶解性,对于优化药物加工和配方至关重要.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 苏尔法萨拉是一种用于治疗炎症疾病的药物.
- 超临界二氧化碳 (scCO2) 是一种具有可调节性质的环保溶剂.
- 了解scCO2中的药物溶解度对于开发先进的药物输送系统至关重要.
研究的目的:
- 为了研究硫沙拉在超临界二氧化碳中的可溶性.
- 为了评估乙醇作为辅溶剂对硫素溶解度的影响.
- 为了确定温度,压力和辅溶剂度对溶解度和密度的影响.
主要方法:
- 溶解度测量在308K至338K的温度和高达30MPa的压力下进行.
- 状态和半经验相关性的SRK方程 (索尔塔尼-马兹鲁米,马德拉斯等). 用于建模可溶性数据.
- 在二进制系统 (硫素-CO2) 和三进制系统 (硫素-乙醇-CO2) 中进行了实验,乙醇度各不相同 (1和3mol%).
主要成果:
- 硫素在scCO2中的溶解度随着温度和压力而增加.
- 作为辅溶剂的乙醇显著提高了硫沙拉的溶解度,与纯的scCO2.2相比,最大增加约为11.95倍.
- 在硫萨拉-乙醇-CO2系统中,在12MPa和338K时观察到最高的溶解度.
- 索尔塔尼-马兹鲁米和马德拉斯等人. 模型与实验溶解度数据有很好的一致性.
结论:
- 乙醇是一种有效的辅溶剂,可以提高硫沙拉在超临界二氧化碳中的可溶性.
- 该研究为优化药物应用中的超临界流体技术提供了有价值的数据.
- 这项研究有助于开发有效和可持续的药物加工和配方方法.
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