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Updated: Sep 18, 2025

Measuring Single-Cell Mitochondrial DNA Copy Number and Heteroplasmy Using Digital Droplet Polymerase Chain Reaction
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Published on: July 12, 2022

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在诱导多能性期间,线粒体蒂米丁代谢和mtDNA复制数的变化

Hyun Kyu Kim1,2, Yena Song1, Minji Kye1

  • 1Soonchunhyang Institute of Medi-bio Science, Soon Chun Hyang University, Cheonan, Republic of Korea.

Experimental & molecular medicine
|June 26, 2025
PubMed
概括

研究人员确定了提米丁激酶2 (TK2) 是诱导多能干细胞重编程过程中减少线粒体DNA的关键基因. 减少TK2表达会影响细胞代谢,但抑制TK2会意外地阻碍重新编程.

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