"怀孕期间补充2'-糖乳糖的微生物和免疫调节:预防食物过敏的策略"
Carole Brosseau1, Anaïs Rousseaux1, Marine Le Romancer1
1INRAE, UR BIA, Nantes, France.
Gut microbes
|June 26, 2025
概括
孕妇在怀孕期间摄入2'-糖乳糖 (2'-FL),一种人类牛奶寡糖 (HMO),有助于肠道健康和后代的免疫发育,提供对食物过敏的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 食物过敏与肠道微生物群的损害,免疫功能障碍和肠道屏障完整性的损害有关.
- 出生时免疫耐受性的失败是食物过敏发展的关键因素.
- 人类牛奶寡糖 (HMO) 在婴儿肠道健康和免疫调节中起着至关重要的作用.
研究的目的:
- 调查孕期补充2exprime-fucosyllactose (2exprime-FL) 对后代食物过敏的保护机制.
- 阐明妊娠期2期前期FL对母体,胎儿和后代肠道微生物群,免疫系统和肠道生理学的影响.
- 了解母体2 extprime-FL摄入量如何影响免疫耐受性和肠道屏障功能的建立.
主要方法:
- 利用小鼠模型来评估孕妇饮食中2 extprime-FL补充剂的影响.
- 使用测序技术分析了母体,胎儿和后代的肠道微生物组成.
- 评估免疫细胞种群,专注于调控性B细胞,在母亲,胎儿和后代.
- 评估肠道屏障完整性和相关的生理标记.
主要成果:
- 孕期2期前期FL补充剂改变了母亲的肠道微生物群组成.
- 在暴露于2 extprime-FL.的母亲,胎儿和后代中观察到调控性B细胞的增加.
- 补充的后代表现出明显的肠道微生物群概况和增强的肠道屏障功能.
- 保护2个extprime-FL后代免受食物过敏的发展,减少过敏症状和生物标志物.
结论:
- 孕妇在怀孕期间摄入2个extprime-FL,在后代的肠道微生物组和免疫系统中建立了持久的有益变化.
- 孕期2期的extprime-FL补充剂促进了调节性B细胞的发展,并加强了肠道屏障,有助于对食物过敏的保护.
- 这项研究提供了有关HMO如何通过调节母婴肠道健康和免疫发育来预防食物过敏的机制性见解.
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