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驳斥辅助生殖技术与自闭症谱系障碍之间的关联:一项案例对照研究
Ronit Kol1, Liat Lerner Geva1, Meirav Shaham2
1Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel.
Journal of child neurology
|June 27, 2025
概括
与典型发育儿童相比,患有自闭症谱系障碍 (ASD) 的儿童使用辅助生殖技术 (ART) 并没有显著差异. ART与ASD的性别或严重程度没有相关性,这令人担心有关联系的担忧.
科学领域:
- 神经发育障碍 神经发育障碍
- 生殖医学 生殖医学
背景情况:
- 自闭症谱系障碍 (ASD) 和辅助生殖技术 (ART) 的发病率同时上升.
- 有关ART与ASD发展之间潜在的关联存在担忧.
研究的目的:
- 通过病例控制研究来调查ART和ASD之间的关联.
- 为了确定ART是否影响ASD的性别分布或严重程度.
主要方法:
- 病例对照研究比较了319名患有自闭症的儿童和319名年龄相匹配的典型发育儿童.
- 分析根据性别,ART类型和ASD严重程度进行了调整.
- 统计分析包括赔率比率和置信区间.
主要成果:
- 在ASD (8.5%) 和典型发育 (9.4%) 组之间,ART使用率相似.
- 在ART和ASD诊断之间没有发现显著的关联 (aOR = 0.537,95%CI 0.110-3.383).
- 激素治疗和体外受精 (IVF) 也没有显示出与ASD有显著的关联.
结论:
- 与对照组相比,在患有自闭症的儿童中,ART并不比对照组更常见.
- ART与ASD的性别或严重程度无关.
- 这些发现令人放心的是,ART和ASD之间没有明显的关联.
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