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干菌Enterococcus和Pediococcus的功能概况:关于益生菌和后生菌性质的体外研究

Mircea-Cosmin Pristavu¹, Filofteia Camelia Diguță¹, Alexandru Constantin Aldea¹

¹Faculty of Biotechnologies, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd., 011464 Bucharest, Romania.

|June 27, 2025

概括

研究人员探索了乳酸细菌 (LAB),如Pediococcus菌株,以获得益生菌和后生菌的益处. 某些菌株表现出强烈的生存,病原体抑制和抗氧化特性,表明功能性食品和疗法的潜力.

科学领域:

微生物学微生物学
食品科学食品科学食品科学
生物技术是生物技术.

背景情况:

抗菌素耐药性 (AMR) 需要新的治疗替代方案.
益生菌和后生菌提供潜在的健康益处和病原体抑制.
乳酸细菌 (LAB) 对这些特性进行了广泛的研究.

研究的目的:

为了评估Enterococcus faecium,Pediococcus acidilactici和Pediococcus pentosaceus菌株的益生菌和后生菌潜力.
识别具有强大的生存率,抗菌活性和有益的生物化学特征的菌株.
评估潜在应用的安全性和功能性质.

主要方法:

16S rRNA测序用于细菌识别.
模拟胃肠道生存,细胞表面分析和酶定位.
安全性评估 (血液溶解,凝酶活性),抗生素敏感性测试和冷干燥生存率.
对抗菌活性,含量 (TPC),黄含量 (TFC) 和FTIR光谱学进行无细胞超浮剂 (CFSs) 的分析.

主要成果:

在模拟的胃肠道条件下,Pediococcus pentosaceus MI124和Pediococcus acidilactici MI129表现出更高的存活率.
包括P. pentosaceus MI124在内的选定菌株显示出强烈的自身聚合和疏水性.
慢性疲劳表现出显著的抗菌活性对抗阳性和阴性病原体,以及显著的抗氧化特性.
所有LAB菌株都表现出高干生存率 (>78.69%).

结论:

几种Pediococcus菌株具有有前途的益生菌特征和后生菌疗效.
鉴定出的菌株显示出潜在的病原体抑制和免疫调节能力.
这些发现支持在功能性食品和治疗应用中使用这些LAB菌株.

关键词:

肠球菌 (Enterococcus faecium) 是一个有毒的菌株.这种病原体是Pediococcus acidilactici.这是一种Pediococcus pentosaceus.后生物潜力是一个后生物潜力.益生菌潜在的益生菌.

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