抗氧化压力保护和抗炎活性的多分离从疹二氧化:在体外研究使用人类皮肤细胞
Katarzyna Wójcik-Borowska1, Weronika Wójciak2, Magdalena Żuk2
1Department of Child Neurology, Medical University of Lublin, 20-093 Lublin, Poland.
Molecules (Basel, Switzerland)
|June 27, 2025
概括
来自Urtica dioica叶和花的多醇显示出显著的抗氧化和抗炎性质. 这些天然化合物保护皮肤细胞免受氧化应激,减少炎症,突出显示它们的化品潜力.
科学领域:
- 皮肤病学和化学
- 植物化学 植物化学
- 细胞生物学 细胞生物学
背景情况:
- 多提供抗氧化和抗炎功效,对于对抗皮肤衰老 (炎症) 至关重要.
- 刺 (Urtica dioica) 被认为是多化合物的丰富来源.
- 在美容学和皮肤病学中存在Urtica dioica提取物的潜在应用.
研究的目的:
- 评估来自Urtica dioica树叶 (UdLs) 和花朵 (UdFs) 的富含多醇的部分的抗氧化和抗炎活性.
- 为了评估这些分数在氧化应激和脂多糖 (LPS) 刺激下对人类皮肤细胞的影响.
主要方法:
- 使用加速溶剂提取和固态提取来分离和净化富含多的分离物.
- 使用二极管阵列检测和质谱仪 (UPLC-DAD-MS) 的超高性能液态染色学分析了化学成分.
- 通过细胞毒性测试,抗氧化能力测试 (DPPH,ABTS,FRAP,CUPRAC,TPC,H2DCFDA),抗氧化酶活性 (SOD,CAT),脂质过氧化 (MDA) 和细胞因子产生 (IL-1β,IL-6,IL-10) 来评估生物活性.
主要成果:
- 无论是UDL和UDF分量都富含多,其中酸占主导地位. 在酸中 UdLs 的含量更高,而 UdF 含有更多的黄酸 (isorhamnetin 衍生物).
- 分子是非细胞毒性的,并显示出强大的激素清除潜力,UdL稍微更有效.
- 这两种分离物显著降低了细胞内活性氧物种 (ROS),增强了抗氧化酶活性,减弱了脂质过氧化,并在刺激的皮肤细胞中降低了促炎性细胞因子分泌.
结论:
- 来自Urtica dioica叶子和花朵的多基分离物具有显著的抗氧化和抗炎性质.
- 这些发现支持使用Urtica dioica提取物作为抗衰老和保护皮肤的化品配方中的多功能成分.
- 这项研究证实了Urtica dioica因其丰富的多含量而具有皮肤和化品应用的潜力.
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