一种有效的口服纳米递送材料的黄素:聪明的利用胃肠道吸收特征
Qiuxu An1, Yuanyuan Liu1, Guodong Liang1
1College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Molecules (Basel, Switzerland)
|June 27, 2025
概括
这项研究开发了一种模仿病毒的纳米载体,以改善口服库尔库的输送. 新的C60-CPP5/Pser@CUR系统增强了粘液的透和细胞吸收,提高了治疗疗效.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 由于可溶性,透性和稳定性较低,黄素口服生物可用性较差.
- 克服生物障碍对于有效的口服药物输送至关重要.
研究的目的:
- 开发一种新型纳米载体,用于增强口服库尔库的输送.
- 模仿病毒策略,以改善粘液透和细胞吸收.
主要方法:
- 构建了一个基于C60富勒伦的纳米载体 (C60-CPP5/Pser@CUR) 用细胞透 (CPP5) 和素.
- 使用电荷逆转策略进行动态表面调制.
- 评估了体外 (Caco-2细胞) 和体内 (大鼠肠道输液) 模型.
主要成果:
- 纳米载体显示Caco-2的细胞吸收比自由黄素高2.26倍.
- 在十二指甲腺和结肠区域显著增强黄素的吸收.
- 与体内自由黄素相比,达到2.60倍的Cmax和14.70倍的AUC0-t.
结论:
- 病毒模仿纳米载体有效地克服了口服输送的生物障碍.
- 动态电荷调制增强了疏水疗法的跨屏障传递.
- 该平台提供了一个强大的策略,用于改善难溶性药物的口服生物可用性.
相关概念视频
Drug Delivery: Enteral Route
747
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
747
Routes of Drug Administration: Enteral
4.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
4.4K
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.0K
Drug Absorption: Factors Affecting GI Absorption
4.8K
The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
4.8K
Drug Delivery: Overview
428
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
428
Factors Influencing Drug Absorption: Anatomical Parameters
293
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
293


