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脂囊泡的物理化学特征用于基于螺旋藻的食补充剂的配送

Massimo Milia¹, Ines Castangia¹, Francesco Corrias¹

¹Department of Life and Environmental Science, University Campus of Monserrato, University of Cagliari, SS 554, 09042 Cagliari, Italy.

Molecules (Basel, Switzerland)

|June 27, 2025

概括

这项研究为螺旋藻提取物开发了先进的封装方法,提高了它们的生物可用性和保护作用. 凝丰富的双体细胞对运动营养和代谢健康补充剂有很大的希望.

科学领域:

生物技术是生物技术.
营养科学营养科学
材料科学材料科学材料科学

背景情况:

螺旋藻 (Arthrospira platensis) 是一种用于体育营养和代谢疾病的微藻.
它的细胞结构阻碍了消化能力和生物活性化合物的可用性.
提取和封装可以提高螺旋化合物的生物利用性和稳定性.

研究的目的:

为了研究脂质体 (Lps),双质体 (Bls) 和质丰富双质体 (G-Bls) 的物理化学特性,用于螺旋藻提取物.
评估这些输送系统的稳定性,释放动力学和生物相容性.
评估G-Bls在减轻氧化应激和增强Spirulina治疗应用中的潜力.

主要方法:

制备和描述Lps,Bls和G-Bls,其中包括螺旋藻提取物.
分析颗粒大小,多分散度指数 (PDI),表面电荷和捕获效率.
在pH 1.2和7.0的体外释放研究以及使用H2O2诱导氧化应激的Caco-2细胞的生物相容性测定.

主要成果:

所有输送系统的粒子尺寸小 (101.8129.7 nm),均性好 (PDI 0.170.33),表面负电荷高,捕获效率高 (>80%).
G-Bls表现出优越的提取物保留,在pH 1.2 (41.8%) 低释放,在pH 7.0 (52.5%) 控制释放.
G-Bls表现出极好的生物相容性 (87.89%的细胞活力在200μg·mL-1) 和显著缓解氧化应激,增加细胞活力.

结论:

凝丰富双体体 (G-Bls) 是螺旋藻提取物的一个非常有前途的输送系统.
G-Bls增强了螺旋藻的稳定性,生物可用性和保护作用.
这些发现支持G-Bls在食补充剂中的潜力,用于体育表现,恢复和代谢障碍管理.

关键词:

双胞胎体中的双胞胎体.富含凝的双体细胞.脂质体是一种脂质体.物理化学特性物理化学特性螺旋藻提取物螺旋藻提取物

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