粘膜PVA薄膜用于持续的复星输送:配方,表征和释放特征
Arleta Dołowacka-Jóźwiak1, Izabela Nawrot-Hadzik2, Adam Matkowski2
1Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Molecules (Basel, Switzerland)
|June 27, 2025
概括
含有白醇 (RSV) 或Reynoutria japonica提取物的聚乙烯醇 (PVA) 薄膜被开发为口腔伤口. 这些粘粘膜具有有利的释放特征和物理化学特性,适用于牙科应用.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔粘膜伤口需要先进的带来有效的愈合.
- 复白 (RSV) 和日本黄 (Reynoutria japonica) 提取物具有治疗性质.
- 聚乙醇 (PVA) 为粘膜药物递送系统提供了合适的基础.
研究的目的:
- 开发和优化基于PVA的聚合物薄膜,其中包括白醇 (RSV) 或Reynoutria japonica提取物.
- 评估这些薄膜作为口腔粘膜伤口带的物理化学特性和治疗适用性.
- 为了比较纯RSV与Reynoutria japonica提取物在开发的薄膜配方中的性能.
主要方法:
- 溶剂造方法用于片制造.
- 电影的特点是厚度,重量,颜色,灵活性,弹性和粘膜强度.
- 实验室释放研究在水和模拟的唾液中进行.
- 评估了水友性和pH值,以确定生理相容性.
主要成果:
- 优化的PVA薄膜 (FR2和FE2) 显示出出色的粘膜粘合性能.
- 在水和唾液中观察到有利的药物释放概况.
- 片表现出适当的物理化学特征,包括水友性和生理pH值.
- 含有RSV和Reynoutria japonica提取物的配方显示出具有明显的口腔伤口愈合潜力.
结论:
- 含有白醇或Reynoutria japonica提取物的PVA基薄膜是口腔粘膜伤口带的有前途的候选者.
- 开发的薄膜具有理想的粘膜和释放特性,可用于牙科应用.
- 这些新的敷料可以提高牙科局部疗法的疗效.
更多相关视频
相关概念视频
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
269
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
269
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
197
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
197
01:16Drug Delivery: Overview
428
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
428