预后免疫和营养指数作为预测胃癌治愈意图切除术患者的生存指数
Soomin An1, Wankyu Eo2, Sookyung Lee3
1Department of Nursing, Dongyang University, Yeongju 36040, Republic of Korea.
Medicina (Kaunas, Lithuania)
|June 27, 2025
概括
预后免疫和营养指数 (PINI) 独立预测手术后胃癌 (GC) 患者的生存率. 将PINI纳入模型可以改善长期生存预测,帮助个性化术后护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 预后免疫和营养指数 (PINI) 在结直肠癌中显示出临床相关性.
- 胃癌 (GC) 预后需要改善患者预后预测工具.
研究的目的:
- 调查PINI作为胃癌 (GC) 患者整体生存期 (OS) 的预后因素的实用性.
- 评估PINI在GC存活的预后模型中的附加值.
主要方法:
- 对492名患有I-III阶段GC,接受治疗性胃切除术的患者的回顾性分析.
- 多变量考克斯回归确定了OS的独立预测因素.
- 模型性能使用C指数,IAUC,时间依赖的AUC,IDI和cnri进行评估.
主要成果:
- 在GC患者中,PINI与OS独立相关 (p < 0.001).
- 包括PINI在内的完整预后模型显著优于TNM分期模型 (p < 0.001).
- 在生存模型中,PINI提高了长期 (5年) 预测准确性.
结论:
- 在手术治疗的GC患者中,PINI是生存的重要独立预测指标.
- 将PINI纳入预后模型可以提高长期生存预测的准确性.
- 在等待外部验证之前,PINI可以为GC患者指导个性化术后管理.
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