复杂菌株 Mycobacterium tuberculosis 的耐药性率:在土耳其进行的一项回顾性研究
Melda Payaslıoğlu1, İmran Sağlık1, Cüneyt Özakın1
1Department of Medical Microbiology, Faculty of Medicine, Bursa Uludağ University, Bursa 16000, Turkey.
Medicina (Kaunas, Lithuania)
|June 27, 2025
概括
耐多药结核病 (MDR-TB) 是一个全球性的健康威胁. 这项研究发现,近20%的结核病分离体对一线药物有耐药性,强调需要持续监测和控制耐药性的努力.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 仍然是一个重要的传染病挑战,特别是在发展中国家.
- 多抗药结核病 (MDR-TB) 是由对一线药物的耐药性引起的,它使全球结核病控制工作复杂化.
- 了解耐药性趋势对于有效的结核病管理至关重要.
研究的目的:
- 为了研究 *Mycobacterium tuberculosis* 菌株药物耐药性模式的时间变化.
- 分析来自土耳其西部一家大型医院的结核病分离体的药物敏感性概况.
- 评估一定的时间内对一线抗结核药物耐药性的流行率.
主要方法:
- 对104,598个用于结核病检测的临床样本 (1996-2023) 的回顾性分析.
- 使用了BACTEC 460 TB,BACTEC MGIT 960和Löwenstein-Jensen介质进行结核菌培养.
- 在 1869 培养阳性分离物上进行了对异化物,利芬素,乙墨托醇和链杆菌素的药物敏感性测试.
主要成果:
- 2.6%的样本为结核病的培养阳性 (2752个隔离物).
- 19.2%的分析分离物 (358/1869) 对至少一种第一线抗结核药物表现出耐药性.
- 2.9%的分离物体对两种或更多的第一线药物表现出耐药性.
结论:
- 药物敏感性测试对于优化治疗和控制耐药结核病至关重要.
- 该研究强调了针对结核病耐药性的持续监测和干预策略的重要性.
- 需要持续努力,才能对抗全球日益增长的MDR-TB威胁.
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