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妊娠中期子宫动脉脉率指数与受孕方法之间的关联:一个队列研究

Antonios Siargkas¹, Ioannis Tsakiridis¹, Dimitra Kappou^2,3

¹Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Medicina (Kaunas, Lithuania)

|June 27, 2025

概括

辅助生殖技术 (ART) 怀孕,特别是那些通过体外受精/细胞内精子注射 (IVF/ICSI) 怀孕的怀孕,在第二个三个月显示下子宫动脉脉动指数 (UtA-PI). 这表明,与自发受孕相比,这些怀孕的子宫胎盘血流可能有所改善.

科学领域:

生殖医学生殖医学
孕产妇和胎儿医学孕产妇和胎儿医学
医疗成像医学成像

背景情况:

辅助生殖技术 (ART) 怀孕与与胎盘相关的不良结果有关.
子宫动脉脉动指数 (UtA-PI) 是胎盘功能的一个关键指标.

研究的目的:

根据受孕方法 (自发性,排卵诱导/子宫内授精,试管婴儿/ICSI) 确定第二个三个月的UtA-PI是否不同.
为了调整影响单独怀孕中UtA-PI的潜在混因素.

主要方法:

对15552个单独怀孕的回顾性队列研究.
自发受孕 (SC),排卵诱导/子宫内授精 (OI/IUI) 和体外受精/细胞内精子注射 (IVF/ICSI) 组之间的UtA-PI值的比较.
多变量线性回归分析根据妊娠年龄,母亲的特征和病史进行调整.

主要成果:

与SC和OI/IUI怀孕相比,IVF/ICSI怀孕的中位数UtA-PI值明显较低 (p < 0.001).与SC和OI/IUI怀孕相比,IVF/ICSI怀孕的中位数UtA-PI值明显较低.
在SC和OI/IUI组之间没有发现UtA-PI的显著差异.
多变量分析证实了IVF/ICSI受孕独立与较低的log10 UtA-PI相关 (估计=-0.076,95%CI:-0.096,-0.056).

结论:

中期子宫动脉多普勒显示IVF/ICSI怀孕的脉动指数较低.
这一发现表明,在ART怀孕中,子宫胎盘血流可能会更好.
需要进一步的研究,以了解与ART相关的妊娠并发症中的母胎相互作用.

关键词:

辅助生殖技术是一种辅助生殖技术.在体外受精体外受精.细胞体内精子注射细胞体内精子注射在子宫内进行授精.中期三个月超声波.排卵诱导诱导排卵诱导胎盘功能胎盘功能第二个三个月的多普勒测试.子宫动脉脉动率指数子宫动脉脉动率指数宫胎盘 perfusion 的使用方法

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