黄素用于2型糖尿病患者和代谢功能障碍相关的脂肪性肝病患者的炎症控制:一项随机对照试验
Metha Yaikwawong1, Laddawan Jansarikit1, Siwanon Jirawatnotai1,2,3
1Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Nutrients
|June 27, 2025
概括
黄素补充剂显著降低了与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的肝脂肪和硬度. 这种黄化合物还改善了炎症和氧化应激标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与炎症和氧化应激有关.
- 库尔库是黄中的一种多,在治疗MASLD方面显示出潜在的潜力.
- MASLD通过脂肪积累和纤维化影响肝脏健康.
研究的目的:
- 评估黄素在减少MASLD患者肝硬化和肝硬化的疗效.
- 为了评估黄素对炎症标志物和氧化应激的影响.
- 为了确定黄素是否能改善MASLD和2型糖尿病患者的肝脏健康参数.
主要方法:
- 一个为期12个月的随机,双盲,安慰剂对照试验.
- 78名2型糖尿病患者和MASLD患者接受了黄素 (1500毫克/天) 或安慰剂.
- 主要结局:瘤坏死因子 (TNF) 的变化;次要结局:炎症性细胞因子,氧化应激标志物和肝脏参数.
主要成果:
- 黄素显著降低了TNF,IL-1β,IL-6和马隆迪甲水平.
- 显著增加了抗氧化酶的活性 (谷氨过氧化酶,超氧化脱酶).
- 黄素补充剂导致肝硬化和肝硬度显著降低.
结论:
- 12个月的黄素补充剂改善了MASLD患者的血糖控制.
- 黄素有效地减少了全身炎症和氧化应激.
- 黄素是一种有前途的辅助疗法,用于管理MASLD,改善肝脏脂肪和硬度.
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