维生素B3 改善临床和临床前研究中的睡眠时间和质量
1School of Nursing, University at Buffalo, The State University of New York, New York, NY 14214, USA.
Nutrients
|June 27, 2025
概括
尼古丁胺基核糖胺 (NR) 是NAD+的前体,可以通过提高NAD+水平来改善睡眠模式. 研究表明,NR有助于睡眠效率和质量,并减少疲劳,特别是在失眠患者中.
科学领域:
- 生物化学 生物化学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- NAD+对于代谢反应和神经保护至关重要,但随着年龄的增长而下降,导致与衰老相关的疾病.
- 尼古丁胺胺 рибоoside (NR),一种维生素B3的形式,是NAD+的前体,可以抵消与年龄相关的NAD+枯竭.
- 虽然NR对睡眠,认知和代谢健康有希望,但它对睡眠模式的具体影响需要进一步调查.
研究的目的:
- 审查当前关于尼古丁胺 рибо补充剂如何影响睡眠模式的科学理解.
- 综合了临床前和人类研究中关于NR对睡眠影响的研究结果.
主要方法:
- 这项研究是对现有科学文献的叙事性审查.
- 它综合了临床前动物模型和人类临床试验的数据.
主要成果:
- 临床前研究表明,NR对时钟基因 (BMAL1,PER2) 的积极影响,并有潜力减轻睡眠剥夺引起的认知障碍.
- 在动物模型中,NR补充改变了睡眠结构,增加了REM睡眠,并减少了NREM睡眠约17%.
- 人类研究表明,NR提高了失眠男性的睡眠效率,提高了睡眠质量,减少了疲劳和老年人的嗜睡.
结论:
- 尼古丁胺 рибо补充剂是提高NAD+水平的可行策略.
- NR显示出作为一种有效干预措施的潜力,可以改善不同年龄组的睡眠障碍和改善睡眠质量.
相关概念视频
01:19Management of Insomnia
328
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
328
01:13Insufficient Sleep and Sleep Deprivation
224
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
224
01:24Substance Use Disorders Affecting Sleep
225
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
225
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
247
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
247
01:11Understanding Sleep
515
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
515
01:15REM Sleep Behavior Disorder
425
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
425