重新调整情绪:精密精神病菌作为抑郁症的辅助或独立治疗,使用来自成年人19项随机对照试验的见解
Alexandra-Eleftheria Menni1, Helen Theodorou2, Georgios Tzikos1
1Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Nutrients
|June 27, 2025
概括
益生菌在减少抑郁症症状方面表现有前途,特别是当与标准治疗一起使用时. 需要进一步的大规模研究来确认对心理健康最有效的菌株.
科学领域:
- 微生物学 微生物学
- 精神病学是一个精神病学.
- 临床医学 临床医学
背景情况:
- 抑郁症是全球残疾的主要原因,许多患者对常规抗抑郁药物没有反应.
- 具有心理作用潜力的益生菌正在成为抑郁症的新治疗策略.
- 本综述侧重于益生菌在治疗抑郁症状方面的疗效.
研究的目的:
- 批判性地审查随机临床试验 (RCT),评估益生菌/精神生菌在缓解抑郁症方面的疗效.
- 在涉及益生菌干预的研究中,使用验证的心理测量工具评估抑郁状态.
- 综合关于益生菌作为抑郁症独立或辅助治疗的证据.
主要方法:
- 对PubMed和Scopus数据库 (2014年1月至2025年1月) 进行了全面的文献搜索.
- 包括RCT在成年人中比较益生菌干预与明确的安慰剂.
- 研究的重点是改善抑郁状态的首要目标.
主要成果:
- 十九个RCT符合纳入标准,所有RCT都显示治疗后抑郁症明显改善.
- 益生菌作为独立疗法 (5项研究) 或辅助疗法 (10项研究) 有效.
- 14项研究显示,比安慰剂显著改善;7/10项辅助和7/9项单独治疗研究显示,与安慰剂相比,有显著的益处.
结论:
- 益生菌,特别是多菌株和特征良好的单菌株,似乎有利于缓解成人抑郁症状.
- 需要大规模的RCT来确定最有效的精神生物菌株.
- 进一步的研究应该集中在明确的益生菌菌株,用于抑郁症管理.
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