叶酸之外:母亲维生素B12在神经管发育中的新兴作用
Lirong Nie1,2, Xinru Liu3, Xiaoxue Li4
1Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, No 38 College Rd, Haidian District, Beijing 100191, China.
Nutrients
|June 27, 2025
概括
维生素B12缺乏与神经管缺陷 (NTDs) 有关,这些缺陷与叶酸水平无关. 补充维生素B12对于与叶酸一起预防NTD至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 发展生物学 发展生物学
背景情况:
- 叶酸 (FA) 补充剂是已知的神经管缺陷 (NTD) 的预防措施之一.
- 维生素B12在NTD发生中的独立作用,与叶酸状况分开,仍然不清楚.
- 现有的研究需要合成来确定维生素B12和NTD之间的关联.
研究的目的:
- 进行现有研究的系统审查和元分析.
- 调查母亲维生素B12水平对NTD风险的独立影响.
- 总结目前关于维生素B12和NTD相关性的证据.
主要方法:
- 在PubMed,Web of Science,Embase和Cochrane数据库中系统地搜索文献.
- 包括在2024年3月1日之前发表的研究.
- 使用标准化平均差异 (SMD) 和95%置信区间 (CI) 的元分析来评估与NTD相关的维生素B12水平.
主要成果:
- 分析了38项研究,涉及来自14个国家的2316例NTD病例和4298例对照.
- 与对照组相比,NTD组观察到显著较低的维生素B12水平 (SMD = -0.23,95% CI [-0.32, -0.14]).
- 尽管叶酸水平在各组之间没有显著差异 (SMD = -0.19,95% CI [-0.28,-0.10]),但母亲的维生素B12度和NTD之间仍然存在显著的关联.
结论:
- 补充维生素B12对于预防神经管缺陷至关重要,补充叶酸.
- 建议在怀孕期间监测母亲的维生素B12度.
- 在NTD预防策略中,应考虑联合补充维生素B12和叶酸.
相关概念视频
Neurulation
42.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.7K
Vitamins
1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K
Teratogenicity
2.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K
Development of Blood Vessels
800
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
800
Role of Vitamins in Maintaining Bone Health
3.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.7K
Role of Hematopoietic Growth Factors
1.7K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.7K


