微生物群可访问的酸盐作为新型和新兴的益生菌促进健康的长寿:当前的研究趋势和前景
Andrei Biţă1,2, Ion Romulus Scorei3, Marvin A Soriano-Ursúa4
1Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania.
Pharmaceuticals (Basel, Switzerland)
|June 27, 2025
概括
富含微生物群可访问的酸盐 (MAB) 复合物的饮食对于健康的肠道微生物群共生 (HMS) 是必不可少的,促进长寿和健康. MABs可以逆转肠道失调,增强免疫力,并加强肠道屏障.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 生物老龄化生物学
背景情况:
- 肠道微生物群失调症 (DYS) 与与年龄相关的疾病和健康的减少有关.
- 通过营养恢复健康的肠道微生物群共生 (HMS) 是长寿的关键策略.
- 微生物群可访问的酸盐 (MAB) 复合物影响HMS.
研究的目的:
- 审查MABs在维持HMS和促进健康的作用.
- 突出MABs在人类饮食中对肠道健康的必要性.
- 探索MABs对衰老和相关疾病的治疗潜力.
主要方法:
- 关于MABs,肠道微生物群和宿主健康的研究文献综述.
- 对MAB机制的分析,包括AI-2B信号和粘液层强化.
- 检查MAB缺乏对肠道微生物群组成和功能的影响.
主要成果:
- MAB对HMS至关重要,影响AI-2B生物合成并抑制病原体.
- 饮食MAB强化了肠道粘液层,逆转DYS,并加强了肠道屏障.
- 缺乏MABs可以降低AI-2B,抑制有益的*Firmicutes*,并损害HMS.
结论:
- 富含MAB的饮食对于健康的HMS至关重要,可以逆转DYS并促进更长的健康寿命.
- 在MAB摄入量,HMS,代谢健康和寿命之间存在联系.
- 针对结肠的基营养药物代表了未来的治疗途径.
更多相关视频
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.7K
09:49Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
22.6K
相关概念视频
Microorganisms in Medicine and Therapeutics
360
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
360
Bacterial Flora of the Large Intestine
653
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
653
Biological Methods for Microbial Control
214
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
214
