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Updated: Jun 24, 2026

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设计,合成和实验室评估4- ((Arylchalcogenyl) 甲基) -1H-1,2,3-triazol-1-yl-menadione:探索它们对抗肺结核的潜力

Nathália L B Santos1, Luana S Gomes1, Ruan C B Ribeiro1

  • 1Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, Niterói 24020-141, RJ, Brazil.

Pharmaceuticals (Basel, Switzerland)
|June 27, 2025
PubMed
概括

新的含化合物显示出作为抗结核病 (抗结核病) 剂的前景. 几种衍生品对Mycobacterium tuberculosis对药物敏感和耐药菌株表现出强烈的活性.

关键词:
1,4-纳夫托基诺的使用.这就是CuAACAC.结核菌菌菌 H37Rv (ATCC 27294) 是一个结核菌.是一种.硫是一种硫.

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.
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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...