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Updated: Sep 18, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

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泰戈普拉赞对移植患者的塔克罗利和酸水平的影响:使用智能试验平台的随机对照研究

Seong-Wook Lee1, You Hyun Jeon1, Jeong-Hoon Lim1

  • 1Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu 41944, Republic of Korea.

Pharmaceuticals (Basel, Switzerland)
|June 27, 2025
PubMed
概括

泰戈普拉桑是一种与竞争的酸阻断剂,在移植接受者中与免疫抑制剂塔克罗利和酸没有相互作用. 这项研究还强调了临床试验中远程监测的有效性.

关键词:
药物相互作用 药物相互作用信息和通信技术信息和通信技术移植脏的情况.基酸盐是什么 基酸盐是什么具有竞争力的酸阻塞剂.这就是塔克罗利斯.这就是Tegoprazan的原因.

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Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
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Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
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