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Updated: Sep 18, 2025

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儿童脑损伤中的神经生长因子:从长椅到床边

Lorenzo Di Sarno1, Serena Ferretti1, Lavinia Capossela1

  • 1Department of Pediatrics, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy.

Pharmaceuticals (Basel, Switzerland)
|June 27, 2025
PubMed
概括

神经生长因子 (NGF) 在治疗儿科创伤性脑损伤 (TBI) 和缺氧缺血性脑病变 (HIE) 中表现有前途. 早期的研究表明,NGF增强神经修复,改善结果,没有显著的不良影响.

关键词:
国家自然资源基金 (NGF)脑损伤是因为脑损伤.孩子们的孩子们的孩子们的孩子们.神经生长因子的神经生长因子神经保护神经保护

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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