在治疗Nirmatrelvir-Ritonavir (Paxlovid) 治疗COVID-19后寻求医疗护理的危险因素:"症状反弹"
Ashish Bhargava1, Susan Szpunar1, Mamta Sharma1
1Department of Medicine, Thomas Mackey Center for Infectious Disease Research, Henry Ford St. John Hospital, 19251 Mack Avenue, Suite 340, Grosse Pointe Woods, MI 48236, USA.
Viruses
|June 27, 2025
概括
尼尔马特里尔维尔加里托纳维尔 (NPR) 治疗COVID-19发现了寻求医疗护理的风险因素. 女性,心肌梗塞,慢性肺病和糖尿病并发症的风险增加,而酒精使用降低了风险.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 尼尔马特雷尔维尔加里托纳维尔 (NPR) 已批准用于患有轻度至中度COVID-19的高风险成年人.
- 对反弹效应的担忧影响了NPR的临床应用.
- 识别患有治疗后医疗护理风险的患者对于优化患者管理至关重要.
研究的目的:
- 为了确定与寻求医疗护理相关的风险因素,在高风险的非住院患者中治疗NPR.
- 分析NPR治疗四周内紧急诊所访问或住院患者入院的综合结果.
主要方法:
- 从2022年1月到2022年12月接受NPR的369名高风险非住院患者的回顾性队列研究.
- 采用多变量逻辑回归分析来确定复合结果的预测因素.
- 评估了关键的人口统计和临床变量,以评估它们与随后寻求医疗护理的相关性.
主要成果:
- 综合结局 (急救诊所访问或住院治疗) 的发生率为6.8% (25/369).
- 寻求医疗护理的重要风险因素包括女性性别 (OR 4.6),心肌梗塞 (OR 4.1),慢性肺病 (不包括喘/COPD) (OR 3.9),并发症糖尿病 (OR 6.9).
- 酒精使用者寻求医疗护理的可能性降低 (OR 0.39).
结论:
- 特定的患者特征,包括女性性别和某些并发症,与NPR治疗COVID-19后寻求医疗护理的风险增加有关.
- 这些发现有助于积极的患者监测和资源分配.
- 需要对更大的队列进行进一步的研究,以验证这些已识别的风险因素.
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