在接种疫苗的炎症性肠病患者中,SARS-CoV-2变体特异性抗体
Eva Ulla Lorentzen1, Richard Vollenberg2, Rieke Neddermeyer1
1Institute of Virology, University of Muenster, Von-Stauffenberg-Str. 36, D-48151 Muenster, Germany.
Vaccines
|June 27, 2025
概括
针对炎症性肠道疾病 (IBD) 接受抗TNF治疗的患者对COVID-19疫苗的免疫反应较弱,特别是针对变种. 对于那些抗体水平较低的人来说,建议提前接种补充疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 胃肠病学 胃肠病学
背景情况:
- 接受抗TNF治疗的炎症性肠病 (IBD) 患者对SARS-CoV-2疫苗接种的免疫反应减弱.
- 评估变异特异性免疫反应对于免疫抑制群体至关重要.
研究的目的:
- 为了研究针对各种SARS-CoV-2变异的抗TNF药物接种疫苗的IBD患者的幽默免疫反应.
- 将这些反应与健康个体的反应进行比较.
主要方法:
- 使用化学发光微粒子免疫测试 (CMIA) 和替代病毒中和测试 (sVNTs) 的试点研究.
- 评估了针对SARS-CoV-2变种的抗体反应性和中和能力 (Alpha,Beta,Gamma,Delta,Omicron BA.1,BA.5).
- 使用VSV伪型病毒中和试验 (pVNT) 作为黄金标准.
主要成果:
- 变种特异性测试证实了SARS-CoV-2变种的免疫逃生特性.
- 接受抗TNF治疗的IBD患者在初始接种疫苗后对Alpha和Omicron变异体的抗体活性显著降低.
- 调整后的截止值显示患者血清中对所有变异的反应性降低.
- 抗TNF治疗显然降低了免疫反应的强度,功能和范围.
结论:
- 变种特定的中和试验对于评估免疫抑制患者的疫苗疗效非常有价值.
- 用抗TNF治疗的IBD患者的抗体水平低于最佳水平,需要考虑早期的强剂疫苗接种和免疫监测.
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