在儿童癌症幸存者中长期疫苗免疫缺陷,尽管有再接种疫苗计划
Alexander Zadruzny1, Eva Tiselius1, Tiia Lepp2
1Division of Pediatric Cancer, Department of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.
Vaccines
|June 27, 2025
概括
儿童癌症幸存者 (CCS) 的结和风疹抗体水平低于对照组,这表明免疫缺口很大. 再接种疫苗的有效性各不相同,MMR对红疹免疫力的影响很小.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 儿童癌症幸存者 (CCS) 面临疫苗可预防疾病的风险增加,原因是癌症治疗损害了幽默免疫力.
- 在CCS中评估疹和红疹抗体的血清流行率对于了解它们的脆弱性至关重要.
研究的目的:
- 为了比较疹和红疹抗体在CCS中的血清流行率与健康对照.
- 研究癌症治疗和再接种疫苗对CCS中疫苗诱导免疫力的影响.
主要方法:
- 在阿斯特里德·林德格伦儿童医院 (2019年3月-2023年1月) 接受治疗的180名CCS患者的回顾性分析.
- 将CCS血清流行数据与15-19岁年龄组的国家血清流行研究进行比较.
- 评估再接种状态及其对抗体水平的影响.
主要成果:
- 与对照组 (92.7%和97.5%) 相比,CCS显示风 (77.7%) 和红疹 (79.1%) 的血清流行率明显较低.
- 强化化疗与最低的破伤风和红疹抗体水平有关.
- 虽然DTP重接种提高了疹免疫力,但MMR重接种对红疹免疫力的影响有限.
结论:
- 在CCS中,疫苗未充分使用和免疫缺口普遍存在,特别是在密集治疗后.
- 在这个队列中,MMR再接种疫苗没有显著增强红疹免疫力.
- 需要有效的策略来恢复CCS不断增长的人群的疫苗免疫力.
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