使用自乳化机制制备含有固定剂量异尼酸-利法辛组合的局部药物输送系统
Melissa van Deventer1, Richard K Haynes1,2, Marius Brits1
1Centre of Excellence for Pharmaceutical Sciences (PharmacenTM), Building G16, Faculty of Health Sciences, North-West University, Potchefstroom 2520, South Africa.
Pharmaceutics
|June 27, 2025
概括
结合异化和利芬素的局部乳液被开发用于皮肤结核病治疗. 橄油微乳液在皮肤输送方面表现有前途,为局部治疗耐药结核病提供了一种新方法.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 微生物学 微生物学
背景情况:
- 结核病 (TB) 是一个主要的全球健康问题,耐药菌株构成了重大挑战.
- 目前的结核病治疗依赖于全身疗法,但局部药物输送系统对皮肤结核病 (CTB) 有潜在的优势.
- 开发针对CTB的局部治疗方法可以提高疗效并减少系统性副作用.
研究的目的:
- 开发和表征局部自乳化药物输送系统 (SEDDS) 对于异化 (INH) 和利芬 (RIF).
- 评估这些配方的稳定性和药物释放性质,用于潜在的CTB治疗.
- 评估橄油微乳液对于皮肤药物递送的适用性.
主要方法:
- 通过设计的质量方法来开发INH和RIF局部乳液.
- 预制剂研究,伪三极形图构造和配方表征 (滴滴大小,泽塔电位,粘度,pH,稳定性).
- 在体外膜释放,皮肤扩散研究和药物稳定性评估.
主要成果:
- 成功制备了包含INH和RIF的自我乳化乳液.
- 橄油微乳液表现出有利的皮肤传递特征,尽管药物扩散到/通过皮肤是无法量化的.
- 利芬素在较高的温度和较低的pH值下显示了降解易感性;然而,所有配方的药物释放都得到证实.
结论:
- 局部自乳化系统可以促进皮肤结核病的直接治疗.
- 橄油微乳液是CTB局部治疗的有希望的载体.
- 需要进一步的研究来优化配方和量化皮肤透率,以获得有效的局部治疗.
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