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关于从半孔纳米载体中释放水友性药物的动态和方法见解

Rodrigo Rozas1,2, Andrea C Ortiz3, Sofía Peñaloza1

  • 1Departamento de Ciencias y Tecnología Farmacéutica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile.

Pharmaceutics
|June 27, 2025
PubMed
概括

选择正确的体外药物释放方法和激发技术对于准确地描述纳米载体释放动力学至关重要. 这项研究比较了三种用于中孔纳米颗粒 (MSN) 的方法,揭示了释放配置和动力学方面的显著差异.

关键词:
药物释放释放药物释放药物释放的时间在体外 (in vitro) 方法.半孔的二氧化纳米粒子.释放研究 释放研究释放测试 释放测试 测试罗达胺 B 类型的胺

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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