通过使用门支室,改善用恒定输出振动网状雾化器雾化布德索尼德悬浮物的肺输送
Tomasz R Sosnowski1, Izabela Kazimierczak1, Aleksandra Sawczuk1
1Faculty of Chemical and Process Engineering, Warsaw University of Technology, 00-645 Warsaw, Poland.
Pharmaceutics
|June 27, 2025
概括
在振动网状雾化器 (VMN) 中添加一个式持有室 (VHC) 显著增加了用于吸入的布德索尼德气溶输送. 这种VMN + VHC系统通过减少呼气损失和优化滴滴大小来提高肺药物可用性.
科学领域:
- 药物通过呼吸道输送.
- 吸入技术是一种吸入技术.
- 制药气溶科学 制药气溶科学
背景情况:
- 振动网状雾化器 (VMN) 适用于肺部药物输送,但缺乏呼气.
- 目前的VMN经常直接连接到接口,导致在呼气过程中药物损失.
- 新型配方和治疗应用正在扩大VMN的使用.
研究的目的:
- 为了评估将一个门保持室 (VHC) 连接到VMN的有效性,以改善布松酸气溶的输送.
- 量化吸入布德索尼德气溶可用于肺部沉积的增加.
- 调查VMN和布松胺产品变异对VHC有效性的影响.
主要方法:
- 在体外实验室研究中使用了七种布德化物 (BUD) 雾化产品 (0.25 mg/mL).
- 在模拟呼吸周期期间,从VMN单独对VMN + VHC系统进行气溶输送速率的重力测量确定.
- 在雾化雾中,激光衍射分析滴滴大小分布.
主要成果:
- VMN + VHC 系统显著增加了可供吸入的气溶和细颗粒物分量.
- 观察到药物总输送量 (T) 的相对增加为30-300%,肺药物可用性 (P) 的相对增加为50-350%.
- VHC通过凝聚/沉积减少了呼气气溶的损失,并通过凝聚/沉积消除了较大的水滴,VMN和BUD产品影响了结果.
结论:
- 在 nebulizing budesonide 悬浮中,VMN + VHC 系统表现出高于单独 VMN 的性能.
- VHC的定量益处是特定于雾化器-腔室-药物组合的,需要经验测试.
- 预测VHC有效性需要对每个系统配置进行个性化评估.
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