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相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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相关实验视频

Updated: Sep 18, 2025

Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
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对于elacestrant二化的新型多态模式

Zia Uddin Masum1, P Grant Spoors2, Matt D Burke2

  • 1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, NY 11439, USA.

Pharmaceutics
|June 27, 2025
PubMed
概括
此摘要是机器生成的。

这项研究确定了elacestrant二化的六种新的晶体模式,扩大了其已知的多态性. 模式A,C和E显示出进一步开发和大规模生产的前景.

关键词:
没有形状的无形.添加了抗溶剂的抗溶剂添加剂.标志性特征的描述.结晶的 结晶的这是一个严格的限制.聚合物模板的模板设计多形态主义的多态主义.溶剂滴滴研磨 溶剂滴滴研磨 是一种

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科学领域:

  • 制药科学 制药科学
  • 固态化学 固态化学

背景情况:

  • 埃拉克斯特兰二化物,由FDA于2023年批准,是一个重要的治疗剂.
  • 之前的研究发现了三种多态形式的elacestrant二化物.

研究的目的:

  • 通过使用各种方法和溶剂,对elacestrant二化进行广泛的多态选.
  • 为了发现新的多态形态形式,超越以前报告的那些.

主要方法:

  • 结晶和无形的酸的溶解度评估.
  • 使用40种非传统溶剂和各种技术进行多态选.
  • 使用X射线粉碎衍射 (XRPD),核磁共振 (NMR),微分扫描热度计 (DSC),热重度计分析 (TGA),离子染色学 (IC) 和高性能液体染色学 (HPLC) 进行固态特征.

主要成果:

  • 广泛的查确定了A,B,C,D,E,F,G的模式,以及以前已知的1和3的形式.
  • 模式A表现出高稳定性,与形式1相比,但晶体产量较低.
  • 模式C,E,F和G被确定为新的多态形式,而模式D被确定为降解剂.

结论:

  • 使用XRPD发现了6种新的elacestrant二化物多态模式 (A,B,C,E,F,G).
  • 模式A,C和E成为了有希望的晶体候选人,用于随后的分析和扩展过程.