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开发3D打印的水凝盘,作为评估辅助剂对美特罗尼达抗菌活性影响的标准化平台

Tomasz Gnatowski¹, Joanna Kwiecińska-Piróg², Tomasz Bogiel³

¹Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 2 Jurasza Str., 85-089 Bydgoszcz, Poland.

|June 27, 2025

概括

这项研究证明了3D打印充满了美特醇 (MET) 的聚乙烯醇 (PVA) 水凝盘. 该方法提供了一个可靠的平台来测试辅助剂对药物疗效的影响,确认可塑剂与MET的兼容性.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
微生物学微生物学

背景情况:

药物输送系统需要精确的配方和对辅助剂与活性药物成分 (API) 相互作用的理解.
无法控制的辅助剂-API相互作用可能会损害药物的稳定性和有效性.
基于聚乙醇 (PVA) 的水凝适用于药物输送矩阵.

研究的目的:

开发和验证一种半固体挤出 (SSE) 3D打印方法,用于创建含有甲化 (MET) 的基于PVA的水凝盘.
建立一个标准化的平台来评估塑化剂对MET抗菌活性的影响.
为了评估MET装载的水凝磁盘的抗微生物疗效,以对抗*Bacteroides fragilis*.

主要方法:

制备PVA水凝油墨,其中包含MET和各种可塑剂 (聚乙烯糖醇400,甘,烯糖醇,二乙烯糖醇单乙烯).
使用SSE3D打印制造标准化水凝盘的制造.
量化MET含量和通过对*B. fragilis*进行磁盘扩散试验评估抗菌活性.

主要成果:

所有含有MET的SSE3D打印水凝矩阵都显示出对*B. fragilis*具有显著的抗菌活性.
测试的塑化剂没有阻碍MET的抗菌疗效.
3D打印过程产生了在MET内容中具有高精度和可重复性的磁盘.

结论:

SSE 3D 打印是一种可行的技术,用于生产可重复的,精确配制的 MET 装载的 PVA 水凝盘.
这种3D打印平台可以对辅助剂对API抗菌性能的影响进行标准化评估.
研究的塑化剂与MET兼容,支持它们在制药配方中的使用.

关键词:

3D打印 (基于挤出方式)这种细菌是 Bacteroides fragilis.抗菌性伤口护理剂抗菌性伤口护理剂药物输送是药物输送的过程.这种水凝是水凝.这种药物是甲尼达.个性化治疗是个性化的治疗.塑化剂塑化剂塑化剂聚乙烯酒精的使用情况

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