将mometasone furoate纳入一个循环德克斯特林金属有机框架,以优化鼻腔给药
Jie Li1,2, Yuhua Guo3, Yan Liu4
1Biological and Pharmaceutical Sciences, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Pharmaceutics
|June 27, 2025
概括
使用循环德克斯特林金属有机框架 (CD-MOFs) 进行莫梅松酸 (MF) 的鼻腔输送,可增强鼻腔中药物的沉积. 这种MF@MOF粉末配方显示出有效治疗慢性鼻炎的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 莫马塔松酸 (MF) 是一种局部皮质类固醇,用于过敏和炎症症状.
- 将MF纳入g-cyclodextrin金属有机框架 (CD-MOF) 产生用于鼻腔输送的MF@MOF粉末.
研究的目的:
- 准备和描述MF@MOF纳米颗粒用于鼻内药物输送.
- 使用3D仿生鼻腔模型评估MF@MOF粉末的鼻腔沉积模式.
主要方法:
- 使用SEM,PXRD,FTIR和热重力测量来表征MF@MOF粒子.
- 用3D打印的仿生鼻腔模型来评估鼻内沉积.
- 通过化时间,温度和MF:CD-MOF比率来优化药物负载.
主要成果:
- 在不改变纳米粒子形态或尺寸的情况下实现了优化药物负载.
- PXRD和FTIR证实了成功地将MF纳入CD-MOF.
- 与45°相比,30°的施用角度增加了呼吸/嗅觉区域的沉积.
- 与传统的鼻喷雾剂相比,MF@MOF鼻粉在呼吸区 (51%的男性,60%的女性模型) 显示了改善的沉积.
结论:
- MF@MOF纳米颗粒适用于鼻内注射.
- 通过MF@MOF传递MF的鼻粉显示了慢性鼻炎治疗的潜力.
- 3D仿生模型有效地模拟了鼻内沉积模式.
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