选择性激光烧结阿托莫克赛丁片:小规模个性化生产的创新方法
Gordana Stanojević1,2, Ivana Adamov3, Snežana Mugoša1,2
1Institute for Medicines and Medical Devices of Montenegro, Ivana Crnojevića 64a, 81000 Podgorica, Montenegro.
Pharmaceutics
|June 27, 2025
概括
选择性激光烧结 (SLS) 3D打印提供了一种灵活的方法来创建个性化的阿托莫丁片. 调整SLS参数可以控制药物释放,从而支持患者特定的药物治疗.
科学领域:
- 制药技术 制药技术 制药技术
- 添加剂制造 添加剂制造 添加剂制造
- 个性化医疗是个性化的医疗.
背景情况:
- 对个性化医学的日益增长的兴趣推动了制药3D打印研究.
- 选择性激光烧结 (SLS) 正在探索小规模,灵活的药物制造.
- 在个性化治疗应用方面研究了阿托莫克赛丁片.
研究的目的:
- 评估SLS 3D打印用于阿托莫克塞丁片生产.
- 为了比较SLS与传统的直接压缩制造.
- 评估SLS参数对药片性质和药物释放的影响.
主要方法:
- 使用SLS 3D打印与不同激光速度制造的阿托莫克赛丁片.
- 与通过压缩模拟器生产的平板电脑进行比较.
- 评估物理性质,药物含量,分解和溶解.
- 对结构和化学完整性的评估 (SEM,FTIR,DSC,XRPD).
主要成果:
- SLS片显示了与压缩片相比较的机械性能和药物含量.
- 较低的激光速度导致更硬的药片,药物释放速度更慢.
- 更高的激光速度产生了具有超快速药物释放率 (> 85%在15分钟内) 的多孔片.
- 所有药片都符合欧洲药典的溶解标准;没有观察到药物辅助剂相互作用或结晶性变化.
结论:
- SLS打印是传统平板电脑制造的一种可行的替代方案.
- 通过参数调整,SLS可以精确控制药物释放概况.
- 该技术为个性化治疗提供了高质量的,针对患者的剂量形式.
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