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脂质聚合物混合纳米颗粒作为体/蛋白质输送的智能药物输送系统
Alharith A A Hassan1,2, Eslam Ramadan1,3, Katalin Kristó1
1Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Pharmaceutics
|June 27, 2025
概括
脂质聚合物混合纳米粒子 (LPHNs) 为口服蛋白质和类药物输送提供了一个有前途的解决方案,克服了传统纳米载体的局限性. 本综述对LPHN进行了分类,并详细介绍了它们的制备方法,强调了它们在改善生物制药输送方面的潜力.
科学领域:
- * 制药纳米技术 * 制药纳米技术
- * 生物材料科学 生物材料科学
- * 药物输送系统 药物输送系统
背景情况:
- *由于不稳定性和酶降解,口服蛋白质和的输送具有挑战性.
- *现有的纳米载体如脂质体和聚合物纳米粒子在生物相容性,稳定性或药物封装方面存在局限性.
- * 脂质聚合物混合纳米粒子 (LPHNs) 结合了脂质和聚合物系统的优势,以改善生物制药的交付.
研究的目的:
- *根据其解剖结构来定义和分类LPHN.
- * 提供LPHN制备方法和影响因素的全面分析.
- * 审查LPHN在口服输送和蛋白质方面的潜力,确定研究缺口和未来方向.
主要方法:
- *文献综述和对LPHNs现有研究的分析.
- *将LPHN分为六种不同的解剖类型.
- *详细检查各种LPHN制备技术 (例如纳米沉,微流体).
主要成果:
- *LPHN提供了增强的稳定性,可控释放,并改善了蛋白质和类药物的生物可用性.
- *根据它们的结构解剖学,已经确定了六个不同的类别的LPHNs.
- *各种制备方法,包括一阶段和两阶段的工艺,都适合LPHN制造.
结论:
- *LPHN代表了口服生物制药输送系统的重大进步.
- *了解LPHN解剖学和制备方法对于优化药物输送至关重要.
- *需要进一步的研究来解决目前的局限性,并充分实现LPHN在治疗应用中的潜力.
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