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通过热挤出和3D打印技术开发纤维化固体分散

Janhavi Deshmukh¹, Kavish Sanil¹, Achref Cherif¹

¹Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, Mississippi, USA.

Pharmaceutical development and technology

|June 27, 2025

概括

这项研究使用热挤出和3D打印开发了纤维酸盐的无形固体分散. 结果的配方显示,与纯纤维酸相比,药物释放的增强.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

开发无形固体分散 (ASDs) 对于改善纤维酸盐等溶解不良药物的生物可用性至关重要.
热挤出 (HME) 和3D打印为创建先进的药物输送系统提供了新的制造技术.
了解制备方法对ASD特性的影响对于有效的药物配方至关重要.

研究的目的:

开发使用热挤出 (HME) 和化沉积建模 (FDM) 3D打印的非形态固体分散 (ASD) 纤维酸盐.
评估HME和3D打印参数,特别是填充密度对纤维酸ASD的性能和性能的影响.
为了比较3D打印的纤维酸盐片与传统制备的囊的药物释放特征.

主要方法:

纤维酸盐 (10% w/w) 通过HME与Soluplus®和聚乙烯氧化物-N80进行处理,以制造纤维.
用于FDM3D打印不同填充密度 (90%,70%,50%) 的平板电脑或成囊的纤维.
使用三点曲试验评估了可打印性;分析了配方的药物含量,物理状态 (SEM,DSC) 和体外药物释放.

主要成果:

在3D打印的配方中,SEM和DSC证实了纤维酸从晶体转化为无形状态的转化.
与纯纤维酸相比,3D打印的药片和囊在体外药物释放量增加了两倍.
填充密度被确定为一个重要的调节参数,影响3D打印平板电脑的药物释放动力学.

结论:

与FDM3D打印相结合的HME是一种可行的方法,用于生产非晶形固体分散的 fenofibrate.
3D打印可以通过调制诸如灌装密度等参数来精确控制药物释放特征.
开发的纤维酸ASD显示显著增强的溶解率,为改善治疗疗效提供了潜力.

关键词:

通过3D打印打印3D打印.菲诺纤维酸盐的使用方法热挤出热挤出固体分散的散发方式可溶性增强提高可溶性

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