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Updated: Sep 18, 2025

Imaging the Human Immunological Synapse
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LAG3-MHCII相互作用诱导在免疫突触处形成紧密的细胞-细胞接口

Zibin Wang1,2, Ting Zhou1, Hanbing Wang3

  • 1State Key Laboratory of Pharmaceutical Biotechnology, MOE Engineering Research Center of Protein and Peptide Medicine, School of Life Sciences, Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China.

Journal of immunology (Baltimore, Md. : 1950)
|June 27, 2025
PubMed
概括

与MHCII结合的淋巴细胞激活基因3 (LAG3) 在免疫突触上形成物理屏障,抑制T细胞功能. 这种相互作用为癌症免疫治疗药物开发提供了新的策略.

关键词:
免疫学的突触.免疫疗法 免疫疗法淋巴细胞激活基因3 3主要组织相容性复合物II类.输血细胞形成的过程

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