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3D生物打印脏结构使用脏特异性的ECM生物墨系统对脏再生进行3D生物打印.

Gabriel Carreno-Caleano1, Mohamed Ali1,2, James J Yoo1

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.

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概括

研究人员从脱细胞化细胞外基质 (kdECMMA) 开发了一种特异的生物墨水,用于3D生物打印. 这种创新的生物墨水支持细胞的生长和成熟,显示出再生受损脏的希望.

关键词:
生物墨水是生物墨水.生物打印是一种生物打印技术.细胞外矩阵是细胞外矩阵.脏 脏 脏 脏的再生 的再生

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科学领域:

  • 再生医学是一种再生医学.
  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.

背景情况:

  • 末期慢性病 (CKD) 是不可逆转的,治疗选择有限,如透析和移植.
  • 3D生物打印为设计功能性结构以修复损伤提供了一个潜在的策略.
  • 开发一种脏特异性的生物墨水对于支持脏细胞组织,成熟和功能至关重要.

研究的目的:

  • 为了利用脏衍生的脱细胞化细胞外基质生物墨水 (kdECMMA) 进行脏组织生物打印.
  • 评估kdECMMA生物墨的可打印性,结构完整性和生物特性.
  • 评估基于kdECMMA的生物打印脏结构用于脏再生的体外和体内可行性.

主要方法:

  • 制备和表征源脱细胞化细胞外矩阵生物墨水 (kdECMMA).
  • 在kdECMMA中封装人类细胞,用于结构的3D生物打印.
  • 在生物打印结构中的细胞活力和成熟的体外评估.
  • 在体内将生物打印结构植入裸体大鼠体内,以评估组织的形成和整合.

主要成果:

  • 该kdECMMA生物墨水显示出出色的打印能力,结构完整性和生物特性.
  • 封装的人类细胞在生物打印结构中显示出高活力和渐进的成熟.
  • 植入的结构展示了新形成的状和管状结构与集成的人类细胞.
  • 无细胞kdECMMA结构也促进了脏组织的形成,这表明宿主原始细胞的招募.

结论:

  • 源脱细胞化细胞外基质生物墨水 (kdECMMA) 是用于组织生物打印的可行材料.
  • kdECMMA支持人类细胞活力,成熟和体内组织再生.
  • 这种方法具有很大的潜力,可以设计脏特定的微环境,以促进脏再生.