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Updated: Sep 18, 2025

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长期高盐饮食通过下调SHANK1诱导认知障碍

Cuiping Guo1,2,3, Yuanyuan Li4, Wensheng Li2

  • 1Institutes of Biomedical Sciences, School of Medicine, Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 27, 2025
PubMed
概括

高盐饮食通过PKA/CREB通路降低SHANK1蛋白水平,从而损害认知功能,导致突触缺陷. 针对这种途径可能为盐引起的认知障碍提供治疗效益.

关键词:
在PKA/CREB中,这就是SHANK1的原因.认知缺陷 认知缺陷高盐的饮食高盐的饮食.突触功能障碍 突触功能障碍

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