瘦身的严重程度会加大穿透导管大动脉植入患者的死亡风险
Kazuma Handa1, Koichi Maeda1, Kyongsun Pak2
1Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.
Interdisciplinary cardiovascular and thoracic surgery
|June 27, 2025
概括
严重的瘦身显著增加了通过导管的大动脉植入 (TAVI) 的患者的死亡风险. 这种情况扩大了住院和中期死亡率,突显了营养状况在TAVI结果中的重要性.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 体重不足,按体重指数 (BMI) <18.5公斤/米2分类,与经过过导管大动脉植入 (TAVI) 的患者的死亡率增加有关.
- 严重瘦身对TAVI后死亡率的具体影响需要进一步调查.
研究的目的:
- 评估TAVI后瘦身严重程度与住院和中期死亡率之间的关联.
- 确定严重的瘦身是否是TAVI后死亡的独立风险因素.
主要方法:
- 分析了来自日本注册的1,804名连续接受TAVI治疗的患者队列.
- 患者被分为严重瘦身,轻度至中度瘦身和正常体重组.
- 评估了住院和中期结果,包括所有原因,心脏和非心脏死亡率.
主要成果:
- 严重瘦身组的住院死亡率明显高 (6.7%) 与其他组相比 (P=0.001).
- 在5年的随访中,严重瘦身组 (77.9%) 的累积全因死亡率明显高于轻度至中度瘦身组 (61.6%) 和正常体重组 (44.4%) (P<0.001).
- 重度瘦身 (aHR,3.00) 和轻度中度瘦身 (aHR,1.35) 被确定为中期死亡的独立风险因素.
结论:
- 严重的瘦身是TAVI后医院死亡率增加的重要预测因素.
- 瘦的程度大大加剧了经过TAVI的患者中期死亡风险.
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