产前暴露于环境温度和早产:一个历史的队列
Selin Girgin1, Offer Erez2,3, Daniel Nevo4
1Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
International journal of epidemiology
|June 27, 2025
概括
怀孕后期高温会增加早产风险,特别是在秋季怀孕时. 怀孕的最后几周最容易暴露于热量,风险因最后一个月经周期的月份而异.
科学领域:
- 环境流行病学环境流行病学
- 生殖健康 生殖健康
- 围产儿医学 围产儿医学
背景情况:
- 越来越多的证据表明,环境温度与早产有关.
- 之前的研究还没有充分探讨易感暴露窗口和群体.
研究的目的:
- 调查敏感的妊娠周和人口群体与温度相关的早产风险.
- 采用一种创新的方法方法来分析产前温度暴露.
主要方法:
- 在以色列南部对131,599个单子活产 (2005-2019) 的历史队列研究.
- 使用时空建模来评估每周的平均温度.
- 应用了与时间依赖的共变量和分布式滞后非线性模型的考克斯模型.
主要成果:
- 高温 (29-37周) 与早产风险增加有关 (HR 1.04 在第37周为99百分位数与最小风险).
- 观察到一个显著的季节性模式,秋季怀孕的风险更高 (LMP在10月:RR 1.17).
- 估计的风险因最后一次月经的月份而异,从6.5%到7.6%.
结论:
- 第三个三个月的最后几周是热量暴露的关键窗口,涉及以色列南部的早产.
- 怀孕的怀孕月份显著影响温度相关的早产风险,秋季怀孕的风险最高.
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