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乳腺癌第四阶段乳腺切除术十年分析:实践模式和结果

Anup Y Parikh¹, Daniil Sokolov¹, Hadley D Freeman¹

¹Department of Surgery, Loma Linda University, Loma Linda, CA, USA.

The American surgeon

|June 27, 2025

概括

乳腺切除术新发转移性乳腺癌 (dnMBC) 患者在与全身治疗相结合时,可能会改善结果,与非手术治疗相比,显示出更高的反应率和更长的存活期.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
乳腺癌研究研究乳腺癌研究

背景情况:

目前的证据缺乏1级数据,支持新发转移性乳腺癌 (dnMBC) 手术治疗的生存益处.
目前,NCCN的指导方针建议乳房切除仅用于dNMBC的息.
多式疗法的进步表明,对于具有长期疾病管理连续性的选择dnmBC患者来说,有潜在的益处.

研究的目的:

评估一次性瘤切除在新发转移性乳腺癌 (dnMBC) 中的作用,在多模式治疗方法中.
为了比较经过乳腺切除术的 dnMBC 患者与未经过乳腺切除术的患者之间的临床病理学因素和患者结果.

主要方法:

在2014-2024年期间接受治疗的92名dnMBC女性患者的回顾性审查.
队列分为手术 (切除乳腺) 和非手术组.
分析临床病理因素,对前期系统治疗的反应和整体存活率 (OS).

主要成果:

乳腺切除术在40%的患者中进行,并与骨疾病相关,而不是广泛的转移.
手术患者在全身治疗后的完全响应率 (32.4%vs12.7%) 和稳定疾病率 (18.9%vs3.6%) 显着更高.
非手术患者的疾病进展率更高 (32.7%vs2.7%),而手术患者的平均寿命更高 (NRvs3.95年).

结论:

主要部位手术可以成为多式治疗新发转移性乳腺癌 (dnMBC) 的宝贵组成部分.
需要进一步的研究来确定dnMBC患者的特定亚组,他们可能从手术干预中获益最多.
为具有挑战性的dnMBC病例提供标准化外科护理,需要在治疗-息连续上对患者进行评估.

关键词:

乳房乳房乳房乳房乳腺癌乳腺癌乳腺癌乳腺瘤学乳腺瘤学

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