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衰老和疾病中的中枢动脉化:当前的证据和知识差距

Peter Lanzer¹, Leon Schurgers², Aleksandra Twarda-Clapa³

¹Middle German Heart Centre, Goitzsche Clinic, Friedrich-Ludwig Jahn Strasse 2, D-06749 Bitterfeld, Germany.

European heart journal

|June 27, 2025

概括

中枢动脉化 (MAC) 是一种无声的衰老过程,加剧心血管风险,特别是在糖尿病和脏疾病中. 对MACM进行进一步研究.

科学领域:

心血管医学心血管医学
血管生物学血管生物学
生物遗传学生物遗传学

背景情况:

中枢动脉化 (MAC) 是动脉衰老的标志,通常是无声的,但是心血管事件,四肢缺血和截肢的关键风险因素,特别是在易受影响的个体中,特别是患有糖尿病和慢性病的人.
马克病变包括血管光滑肌细胞表型切换,导致氧酸盐沉积,中间层破坏和内脏加厚.
在衰老和疾病中共享的信号通路有助于MAC,通过动脉硬化和内脏加厚,从根本上改变血液动力学.

研究的目的:

强调中枢动脉化 (MAC) 作为心血管发病率和死亡率的风险因素的关键作用.
为了强调缺乏对MAC对血液动力学影响的全面理解.
强调需要进一步研究MAC的分子病原和血液动力学后果,以便早期检测,预防和治疗.

主要方法:

审查关于中枢动脉化 (MAC) 病原,临床影响和血液动力学影响的现有文献.
分析MAC的生物特征,包括血管光滑肌肉细胞表型切换和酸沉积.
讨论目前用于检测早期MAC的诊断局限性 (脚-手腕指数,超声波,X射线).

主要成果:

中枢动脉化 (MAC) 是动脉衰老的重要因素,也是心血管疾病和肢体威胁性缺血的关键风险因素.
马克导致动脉硬化和内脏厚,导致显著的,但不完全理解的血液动力学变化.
目前的临床检测方法仅限于MAC的晚期阶段,这凸显了早期诊断的差距.

结论:

中枢动脉化 (MAC) 由于进展缓慢,为早期检测,预防和干预提供了许多机会.
由于缺乏有效的药理疗法,因此需要进一步研究MAC的分子机制和血液动力学影响.
制定预防,逆转或延迟MAC的策略至关重要,因为重血管化仍然是症状患者的主要治疗方法.

关键词:

慢性脏疾病慢性脏疾病糖尿病是一种糖尿病.媒体硬化症蒙克贝格 (Mönckeberg)中枢动脉化中枢动脉化血管衰老血管衰老血管遗传学血管遗传学血管分子生物学血管分子生物学血管病理学血管病理学

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