Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

874
Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
874
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

631
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
631
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

480
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
480
Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

1.0K
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
1.0K
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

397
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
397

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

From promise to practice: why HRMS has yet to fully revolutionize forensic toxicology.

Journal of analytical toxicology·2025
Same author

Trends in central/peripheral ratio of fentanyl in Harris County, TX, and Orange County, CA, from 2009 to 2020.

Journal of analytical toxicology·2024
Same author

Mitragynine in the Orange County DUID population.

Journal of analytical toxicology·2023
Same author

A Two-Year Review of Fentanyl in Driving under the Influence and Postmortem Cases in Orange County, CA, USA.

Journal of analytical toxicology·2022
Same author

Cannabinoid Stability in Antemortem and Postmortem Blood.

Journal of analytical toxicology·2019
Same author

The Trouble With Kratom: Analytical and Interpretative Issues Involving Mitragynine.

Journal of analytical toxicology·2019

相关实验视频

Updated: Sep 18, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.7K

在死后法医病例中使用蒂桑尼丁.

Laura Friederich1, Dani Mata2, Sandra Bishop-Freeman1,3

  • 1Division of Public Health, Department of Health and Human Services, North Carolina Office of Chief Medical Examiner, NC, USA, 4312 District Dr, Raleigh, 27607.

Journal of analytical toxicology
|June 27, 2025
PubMed
概括

法医毒理学家应该注意tizanidine,一个α-2上腺素受体激动剂,由于其潜在的毒性. 这项研究回顾了死后病例,以帮助区分治疗和致命的tizanidine度.

更多相关视频

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.4K
Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans
12:32

Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans

Published on: September 27, 2020

8.8K

相关实验视频

Last Updated: Sep 18, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.7K
Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

2.4K
Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans
12:32

Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans

Published on: September 27, 2020

8.8K

科学领域:

  • 法医毒理学 法医毒理学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 像tizanidine这样的α-2上腺素受体激动剂用于各种医疗条件.
  • 提扎尼丁在法医毒理学中较少被发现,对其死前和死后度的数据有限.
  • CYP1A2 抑制剂可以增加蒂桑尼丁水平,增加毒性风险,而伊米达林受体活性有助于其作用.

研究的目的:

  • 在18个案例中分析了死后的tizanidine度.
  • 为了建立tizanidine的法医毒理学概况.
  • 在死后调查中帮助区分治疗和有毒/致命度.

主要方法:

  • 对18个涉及tizanidine的死后病例的审查.
  • 病理学家将病例分类为"自杀"",意外"和"偶然".
  • 在不同类别的病例中分析和比较tizanidine度.

主要成果:

  • 自杀病例 (N=8) 的平均tizanidine度为6.2 mg/L (中位数为0.77 mg/L).
  • 事故病例 (N=4) 的平均tizanidine度为0.86 mg/L (中位数为0.89 mg/L).
  • 偶尔发生的病例 (N=6) 的平均tizanidine度为0.35 mg/L (中位数为0.035 mg/L).

结论:

  • 蒂扎尼丁度因死亡方式而有显著差异.
  • 这些数据可以帮助法医毒理学家解释死后的tizanidine水平.
  • 案件调查细节对于确定死亡原因和方式至关重要.